Up to 72 percent of adolescents with myelodysplastic syndrome (MDS), and monosomy 7 have the GATA2 mutation. Approximately one-half of the cases of GATA2 deficiency result from a germline mutation and is heritable.
Oncology nurses and providers are in a unique position to impact these outcomes by obtaining detailed and accurate family histories to optimize treatment decisions, especially for patients with MDS and/or AML. Research has shown that GATA2 patients that undergo stem cell transplantation prior to development of life-threatening infections or cytogenetic abnormalities have better outcomes.Interventions: An accurate family history is a valuable, inexpensive, and often underused tool. Please read the latest conference abstract on the Importance of obtaining an accurate family history.
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